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Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis
Flavia G Nunes Rosado1, Charles W Stratton, Claudio A Mosse
1Department of Pathology, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, USA. flavia.nunes@vanderbilt.edu
Context:
Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing.
Objective:
To assess and compare the histopathologic and epidemiologic features of common and uncommon pediatric bacterial lymphadenitis.
Design:
We searched our database for surgical specimens that had a positive identification of bacteria during an 8-year period. The chart was reviewed to assess the pathogen identified and epidemiologic data. The archival tissue sections were reviewed and the histopathologic findings described for each pathogen.
Results:
The review of 368 pediatric lymph node biopsies identified 33 cases with a bacterial infection. These comprised 21 cases of Mycobacterium avium complex (60%), 1 of Mycobacterium fortuitum (3%), 7 of Bartonella henselae (20%), 2 of Yersinia enterocolitica (7%), 1 of Francisella tularensis (3%) and 1 of Streptococcus pyogenes (3%).
Conclusions:
Each of these infectious lymphadenitides had distinct epidemiologic and histopathologic features that are discussed in this report.
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