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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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[Chemotherapy in male external genital organs (testicular and penile cancer)].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2013
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Related Experiment Video

Updated: May 28, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

[Chemotherapy in urologic oncology].

J-L Deville1

  • 1Service d'oncologie médicale, CHU Timone, France. jean-laurent.deville@sfr.fr

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|October 29, 2011
PubMed
Summary

Chemotherapy is effective for localized and metastatic urologic cancers as part of a multidisciplinary approach. For most metastatic urologic cancers, it offers palliative care, with specific indications for bladder and prostate cancers, and anti-angiogenic drugs for renal carcinomas.

Related Experiment Videos

Last Updated: May 28, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

Area of Science:

  • Urologic Oncology
  • Medical Oncology
  • Cancer Treatment

Context:

  • Chemotherapy plays a crucial role in managing localized and metastatic urologic cancers.
  • It is integrated into a multidisciplinary strategy involving surgery, oncology, and radiotherapy.
  • The efficacy and role of chemotherapy vary significantly across different urologic cancer types and stages.

Purpose:

  • To outline the current role and indications of chemotherapy in various urologic malignancies.
  • To differentiate the application of chemotherapy in localized versus metastatic disease.
  • To highlight alternative therapeutic options for specific urologic cancers where chemotherapy is not indicated.

Summary:

  • Chemotherapy is a standard treatment for localized and metastatic urologic cancers, often within a multidisciplinary framework.
  • For metastatic testicular germ cell cancers, chemotherapy is curative. For other metastatic urologic cancers like bladder and castration-resistant prostate cancer, it provides palliative benefits.
  • In metastatic clear cell renal carcinoma, chemotherapy is contraindicated, with anti-angiogenic drugs being the primary treatment. Neoadjuvant chemotherapy is standard for muscle-invasive bladder cancer in eligible patients.

Impact:

  • Provides clarity on chemotherapy's role in urologic oncology, guiding treatment decisions.
  • Emphasizes the importance of tailored therapeutic strategies based on cancer type and stage.
  • Highlights the evolving landscape of cancer treatment, including the rise of targeted therapies like anti-angiogenic drugs.