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Updated: May 28, 2026
06:52
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Single-shot turbo spin-echo diffusion-weighted imaging for retinoblastoma: initial experience.
P de Graaf1, P J W Pouwels, F Rodjan
1Department of Radiology, VU University Medical Center, Amsterdam, the Netherlands. p.degraaf@vumc.nl
AJNR. American Journal of Neuroradiology
|October 29, 2011
Summary
Diffusion-weighted imaging (DWI) using HASTE sequences effectively characterizes retinoblastoma in children. Apparent diffusion coefficient (ADC) maps help differentiate viable from necrotic tumor tissue, aiding treatment monitoring.
Area of Science:
- Ophthalmology
- Radiology
- Oncology
Background:
- Retinoblastoma exhibits variable diffusion-weighted imaging (DWI) hyperintensities.
- Standard echo-planar (EP) DWI is challenged by orbital susceptibility artifacts.
- Novel DWI techniques are needed for accurate retinoblastoma assessment.
Purpose of the Study:
- To evaluate the feasibility of single-shot turbo spin-echo (HASTE) DWI for retinoblastoma.
- To assess the utility of apparent diffusion coefficient (ADC) maps in distinguishing viable from necrotic tumor tissue.
Main Methods:
- Conventional MRI, HASTE DWI, and ADC maps were analyzed in 17 retinoblastoma patients.
- Non-EP HASTE DWI used b-values of 0 and 1000 s/mm(2).
- ADC values were measured in enhancing and nonenhancing tumor regions and compared with histopathology.
Main Results:
- Vital tumor tissue showed hyperintensity on DWI.
- Statistically significant differences in mean ADC values were found between enhancing (viable) and nonenhancing (necrotic) tumor tissues.
- Low ADC values correlated with viable tumor, while intermediate values correlated with necrosis.
Conclusions:
- HASTE DWI is feasible for retinoblastoma evaluation in children.
- ADC maps are valuable for differentiating viable and necrotic retinoblastoma.
- ADC may assist in monitoring therapeutic response in eye-preserving treatments.
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