Related Experiment Video
Updated: May 28, 2026
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
The interpolated projection data estimation method improves the image quality of myocardial perfusion SPECT with a
Kimie Asao1, Akihiro Takaki, Mitsuhiro Tominaga
1Division of Radiological Science, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan.
Objective:
The interpolated projection data estimation processing (IPDE) method increases the amount of projection data by interpolation of the projection data. We examined the usefulness of the IPDE method for (201)Tl myocardial perfusion imaging (MPI) single photon emission computed tomography (SPECT) with a short acquisition time.
Methods:
Forty patients with suspected ischemic heart disease underwent stress (201)Tl-MPI SPECT. Both stress and delayed images were acquired with 4 cycles of 360° continuous rotation with a 90-direction setting for 14 min. The projection data used for reconstruction were 1) all cycle data (Tl-90-14min), 2) 2 cycles of data (Tl-90-7min), and 3) 2 cycles of data processed using the IPDE method (Tl-180IPDE-7min). This study compared the detection of the perfusion defect by the uptake score and the image quality of (201)Tl-MPI SPECT using the normalized mean square error (NMSE).
Results:
The uptake score of Tl-180IPDE-7min was significantly more concordant with Tl-90-14min in comparison to the Tl-90-7min (p < 0.05). The NMSE of the Tl-180IPDE-7min (1.85 ± 1.06%) was significantly lower than that of the Tl-90-7min (2.07 ± 1.24%) (p < 0.05). The degree of improvement by the IPDE method was significantly greater for the delayed (201)Tl-MPI SPECT than for the stress (201)Tl-MPI SPECT (p < 0.05).
Conclusion:
The IPDE method improved the image quality and secured the diagnostic ability of (201)Tl-MPI SPECT for a short acquisition time. Furthermore, the IPDE method is a simple software program that does not require any expensive equipment or use advanced algorithms. These results suggest that the IPDE method may be useful as an adjunctive method for shortening the acquisition time of (201)Tl-MPI SPECT.
