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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...

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Related Experiment Video

Updated: May 28, 2026

Preservation of Porcine Donation after Circulatory Death (DCD) Liver by Perfusion and Orthotopic Liver Transplantation
05:25

Preservation of Porcine Donation after Circulatory Death (DCD) Liver by Perfusion and Orthotopic Liver Transplantation

Published on: June 14, 2024

Oxygen persufflation as adjunct in liver preservation (OPAL): study protocol for a randomized controlled trial.

Thomas Minor1, Carolin Pütter, Anja Gallinat

  • 1Surgical Research Division, University Clinic of Surgery, Bonn, Germany. minor@uni-bonn.de

Trials
|November 1, 2011
PubMed
Summary

Hypothermic oxygen persufflation improves liver graft recovery after transplantation. This method reconditions organs, reducing injury and enhancing survival for marginal liver grafts.

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Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
09:29

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

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Last Updated: May 28, 2026

Preservation of Porcine Donation after Circulatory Death (DCD) Liver by Perfusion and Orthotopic Liver Transplantation
05:25

Preservation of Porcine Donation after Circulatory Death (DCD) Liver by Perfusion and Orthotopic Liver Transplantation

Published on: June 14, 2024

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
09:29

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Area of Science:

  • Transplantation immunology
  • Organ preservation
  • Graft viability

Background:

  • Early graft dysfunction after liver transplantation is often caused by preservation/reperfusion injury.
  • Increasing donor organ criteria due to shortages heightens graft susceptibility to ischemic damage.
  • Post-preservation injury primarily occurs during warm reperfusion, not cold storage.

Purpose of the Study:

  • To confirm if hypothermic reconditioning with oxygen persufflation can improve the recovery of marginally preserved liver grafts.
  • To investigate the potential of oxygen persufflation to suppress injurious cellular activation cascades.
  • To evaluate the efficacy of transient hypothermic reconditioning after standard procurement and cold storage.

Main Methods:

  • A prospective, single-center, randomized proof-of-concept study (OPAL) involving 116 liver transplant patients.
  • Two parallel groups: one receiving 2-hour oxygen persufflation of the liver graft pre-transplant, the other standard cold storage.
  • Primary endpoint: peak serum AST levels within 3 days post-transplant; secondary outcomes include survival, ICU stay, and graft function scores.

Main Results:

  • The study aims to assess the effect of oxygen persufflation on reducing parenchymal liver injury, indicated by peak AST levels.
  • Further outcomes include evaluating patient and graft survival rates, intensive care unit (ICU) requirement duration, and early graft dysfunction.
  • Molecular analysis will explore the impact on autophagy and inflammatory cell activation pathways.

Conclusions:

  • Hypothermic reconditioning by oxygen persufflation is hypothesized to be a beneficial method for improving post-ischemic liver graft recovery.
  • This technique may suppress injurious cellular activation cascades, thereby enhancing the viability of compromised liver grafts.
  • The study seeks to provide evidence for the clinical utility of oxygen persufflation in liver transplantation.