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Related Experiment Videos

Retrovirus phylogeny and evolution.

R F Doolittle1, D F Feng, M A McClure

  • 1Department of Chemistry, University of California, San Diego, La Jolla 92093.

Current Topics in Microbiology and Immunology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Analyzing retroviral genomic sequences reveals four main groups, blurring lines between exogenous and endogenous viruses. This suggests a dynamic balance between germline invasion and viral escape, with shared ancestry among retroviruses and retrotransposons.

Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Genomics

Background:

  • Complete genomic sequences of retroviruses and retrotransposons are available.
  • Phylogenetic analysis of these sequences can reveal evolutionary history.

Purpose of the Study:

  • To construct sequence-based phylogenies of retroviruses and retrotransposons.
  • To investigate the evolutionary relationships and history of these genetic elements.

Main Methods:

  • Elucidation of complete genomic sequences.
  • Construction of sequence-based phylogenies.
  • Residue-by-residue character assessment.

Main Results:

  • True retroviruses cluster into four major groups, with no distinction between exogenous and endogenous forms.

Related Experiment Videos

  • Exogenous and endogenous retroviruses show comparable evolutionary limb lengths.
  • Retroviruses share common ancestry with retrotransposons and other reverse transcriptase-bearing entities.
  • The Gypsy group of retrotransposons shows closer resemblance to the Moloney mouse group of retroviruses than to other retroviruses.

    • Conclusions:

    • Evidence supports a dynamic equilibrium between germline invasion by infectious retroviruses and escape of endogenous viruses.
    • The Gypsy retrotransposon and Moloney mouse retrovirus similarity is best explained by slower evolutionary rates, not recent common ancestry.