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Related Experiment Video

Updated: May 28, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

A step-by-step guide to systematically identify all relevant animal studies.

Marlies Leenaars¹, Carlijn R Hooijmans, Nieky van Veggel

¹3R Research Centre, Central Animal Laboratory, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. M.Leenaars@cdl.umcn.nl

Laboratory Animals

|November 1, 2011

Summary

This summary is machine-generated.

Performing systematic reviews requires comprehensive literature searches for animal studies. A new step-by-step guide aids researchers in finding all relevant evidence, improving review quality and preventing redundant animal experiments.

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Area of Science:

* Preclinical and fundamental animal research.
* Scientific methodology and literature review.

Background:

* Thorough analysis of prior animal experiments is crucial for scientific integrity and ethical considerations.
* Systematic reviews (SRs) are the optimal method for analyzing existing animal research literature.
* Comprehensive literature searches are essential for SRs to minimize bias and ensure accurate interpretation of results.

Purpose of the Study:

* To address the challenge of finding all relevant animal studies for systematic reviews.
* To provide a practical, step-by-step guide for conducting thorough literature searches in animal research.
* To improve the quality of systematic reviews and reduce unnecessary animal experimentation.

Main Methods:

* Development of an easy-to-use, step-by-step guide for searching animal studies.
* Optimization of the guide based on feedback from scientists in animal experimentation.
* Focus on structured, thorough, and transparent literature searching techniques.

Main Results:

* The developed guide facilitates a comprehensive search for animal studies.
* The guide is designed to be applicable to both preclinical and fundamental science research.
* It aims to enhance the scientific quality of resulting systematic reviews.

Conclusions:

* A structured approach to literature searching is vital for robust animal research reviews.
* The new guide assists researchers in conducting comprehensive searches, improving scientific rigor.
* Effective literature searching can prevent redundant animal studies, promoting ethical research practices.