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Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress

Hatem Arı1, Mehmet Tokaç, Yusuf Alihanoğlu

  • 1Clinic of Cardiology, Beyhekim State Hospital, Konya, Turkey. hatem_ari@hotmail.com

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|November 1, 2011
PubMed

Insights

Heart-type fatty acid binding protein (H-FABP) levels did not increase after exercise stress testing (EST) in patients with coronary artery disease (CAD). Instead, H-FABP levels decreased, possibly due to exercise-induced proteinuria.

Area of Science:

  • Cardiology
  • Biochemistry
  • Diagnostic Markers

Background:

  • Stable coronary artery disease (CAD) lacks a specific diagnostic marker.
  • Myocardial damage markers have improved for acute coronary syndromes, but not for stable CAD.
  • Heart-type fatty acid binding protein (H-FABP) is a potential biomarker.

Purpose of the Study:

  • To investigate the relationship between stable coronary artery disease (CAD) and changes in heart-type fatty acid binding protein (H-FABP) levels.
  • To evaluate H-FABP levels before and after exercise stress testing (EST).

Main Methods:

  • Observational study with 47 participants (26 with CAD, 21 controls).
  • H-FABP levels measured at baseline, peak exercise, 1-hour, and 3-hours post-exercise.
  • Statistical analysis using Friedman and Wilcoxon tests with Bonferroni correction.

Main Results:

  • H-FABP levels decreased from baseline to 3-hours post-exercise in both CAD and control groups.
  • The decrease in H-FABP was statistically significant in both groups (p<0.05).
  • A more pronounced significant decrease in H-FABP was observed in the CAD group compared to controls (p=0.009).

Conclusions:

  • H-FABP levels did not increase during exercise stress testing (EST).
  • H-FABP levels showed a tendency to decrease post-exercise.
  • The observed decrease in H-FABP may be attributed to exercise-induced proteinuria.
Abstract

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