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Altered neurophysiologic response to intermittent theta burst stimulation in Tourette syndrome
Steve W Wu1, Donald L Gilbert1
1Cincinnati Children's Hospital Medical Center, Division of Neurology, Cincinnati, Ohio.
Background:
The motor system in Tourette syndrome has been found to be abnormal in previous fine-motor and neurophysiologic studies.
Objective:
This novel pilot study uses repetitive transcranial magnetic stimulation as a method to characterize the neurophysiology of the motor system in Tourette syndrome.
Method:
We investigated the modulation of cortical excitability in adult Tourette syndrome patients by measuring motor-evoked potential amplitudes before and after applying intermittent theta burst transcranial magnetic stimulation.
Results:
Motor-evoked potential amplitude changes over 1 and 10 minutes after intermittent theta burst transcranial magnetic stimulation were greater in 11 healthy controls than 10 adult patients with Tourette syndrome (P = 0.004).
Conclusions:
This altered neurophysiologic response to intermittent theta burst stimulation may contribute to the understanding of motor cortical mechanisms in Tourette syndrome.
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