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Bladder mechanoreceptor changes after artificial bladder outlet obstruction in the anesthetized rat
Jianwen Zeng1, Keji Xie, Chonghe Jiang
1Department of Urology, Qingyan City People's Hospital, Jinan University, Guangdong, China.
Neurourology and Urodynamics
|November 1, 2011
Summary
Bladder outlet obstruction (BOO) in rats alters bladder mechanoreceptors, increasing threshold volumes and reducing tension sensitivity. These changes may explain residual urine development in benign prostatic hyperplasia (BPH).
Area of Science:
- Urology
- Physiology
- Experimental Medicine
Background:
- Bladder outlet obstruction (BOO) in humans causes detrusor hypertrophy, instability, frequency, and residual urine.
- Animal models are crucial for understanding the mechanisms behind BOO symptoms like residual urine.
- Benign prostatic hyperplasia (BPH) is a common cause of BOO in men.
Purpose of the Study:
- To investigate the mechanisms of residual urine development in a rat model of BOO.
- To examine changes in bladder mechanoreceptor tension sensitivity in response to BOO.
- To correlate these changes with the degree of obstruction and residual urine formation.
Main Methods:
- Female Sprague-Dawley rats underwent either BOO or sham surgery.
- Cystometrograms and bladder afferent activity were recorded.
- Mechanoreceptor tension sensitivity was assessed by plotting afferent response against bladder pressure; bladder weight indicated obstruction severity.
Main Results:
- Obstructed rats showed increased bladder weight, capacity, and micturition threshold volume.
- The threshold volume for afferent activation was significantly higher in BOO rats (0.60 ml vs. 0.15 ml) and correlated with bladder weight.
- Bladder mechanoreceptors in obstructed rats had lower tension sensitivity and normalized pressure-response function slopes.
Conclusions:
- Rats with BOO exhibit bladder mechanoreceptors with elevated threshold volumes and diminished tension sensitivity.
- These alterations likely lead to a reduced afferent signal for the micturition reflex.
- Such functional changes in mechanoreceptors may contribute to urinary retention and residual urine in BOO patients, including those with BPH.
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