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Updated: May 28, 2026
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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
[Update on surgery for diffuse low-grade gliomas: brain mapping, hodotopy and neuroplasticity]
1Neurochirurgie, Hôpital Gui de Chauliac, CHU Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier, France. h-duffau@chu-montpellier.fr
Bulletin De L'Academie Nationale De Medecine
|November 2, 2011
Summary
Active management with early radical surgery is now recommended for diffuse low-grade gliomas (DLGG). This approach delays cancer progression and improves survival, even in eloquent brain areas.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Neuroplasticity
Context:
- Understanding of diffuse low-grade gliomas (DLGG) natural history and brain plasticity has evolved.
- Shift from "wait and see" to active therapeutic management for DLGG.
- Advances in functional mapping (preoperative neuroimaging, intraoperative awake surgery) challenge classical brain organization models.
Purpose:
- To highlight the paradigm shift in DLGG management.
- To emphasize the benefits of early radical surgical resection.
Summary:
- Early radical surgical resection is the current first-line treatment for DLGG.
- This strategy delays anaplastic transformation and significantly increases median survival.
- It preserves or improves quality of life, even for gliomas in eloquent areas.
Impact:
- Early surgical intervention offers improved outcomes for DLGG patients.
- Hodotopic model of dynamic brain networks supports surgical interventions in eloquent areas.
- This approach redefines the management of previously unresectable gliomas.
