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Updated: May 28, 2026
09:29
Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
Published on: May 18, 2017
[Protein post-translational modification and age-related cataract]
1Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|November 2, 2011
Summary
Age-related cataract, a leading cause of vision impairment, is linked to protein post-translational modifications like deamidation, glycation, and oxidation. Understanding these changes may lead to new protective strategies beyond surgery.
Area of Science:
- Ophthalmology
- Biochemistry
- Molecular Biology
Context:
- Age-related cataract is the primary cause of vision impairment globally.
- Protein post-translational modifications significantly impact lens protein structure and solubility.
- Current cataract management is predominantly surgical.
Purpose:
- To review the relationship between various protein post-translational modifications and age-related cataract.
- To explore potential protective methods targeting protein modification processes.
Summary:
- Protein post-translational modifications, including deamidation, glycation, and oxidation, are implicated in age-related cataract formation by altering crystallin structure and solubility.
- Acetylation and methylation may offer protective effects on lens proteins.
- This review examines these modifications and discusses strategies to mitigate cataract progression.
Impact:
- Provides insights into the molecular mechanisms underlying age-related cataract.
- Highlights potential therapeutic targets for preventing or slowing cataract development.
- Informs future research directions in ophthalmology and protein biochemistry.
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