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Updated: May 28, 2026

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
Published on: March 21, 2025
Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating
Valeria Castelletto1, Ge Cheng, Ian W Hamley
1Dept of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Abstract:
A series of heptapeptides comprising the core sequence Aβ(16-20), KLVFF, of the amyloid β peptide coupled with paired N-terminal γ-amino acids are investigated in terms of cytotoxicity reduction and binding to the full Aβ peptide, both pointing to inhibition of fibrillisation for selected compounds. This is related to the self-assembly capacity of the heptapeptides.
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