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Published on: December 7, 2016
Comparison between one injection and three monthly injections of intravitreal bevacizumab for myopic choroidal
Yuichi Niwa1, Osamu Sawada, Taichiro Miyake
1Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan. yuichi @ belle.shiga-med.ac.jp
Aim:
To compare the effects of one intravitreal bevacizumab (IVB) injection with three monthly injections for myopic choroidal neovascularization.
Methods:
Group A included 13 patients treated with one IVB injection; group B included 19 patients treated with three monthly 1.25-mg IVB injections. All patients were followed monthly for 12 months with additional injections performed as needed. The best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment.
Results:
The mean logMAR BCVA improved from 0.59 to 0.49 at 12 months in group A (p = 0.21) and from 0.65 to 0.29 in group B (p < 0.001); the improved logMAR BCVA differed significantly between the groups (p < 0.05). The mean CFT decreased from 231 μm at baseline to 150 μm at 12 months in group A (p < 0.05) and from 279 to 156 μm in group B (p < 0.001). During the follow-up, 6 of 13 eyes in group A and 5 of 19 eyes in group B received additional injections.
Conclusions:
Treatment starting with three monthly IVB injections may achieve better functional outcomes with fewer retreatments compared with treatment starting with one IVB injection.
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