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Ossifying trichilemmal cyst.

Teresa Pusiol1, Doriana Morichetti, Maria Grazia Zorzi

  • 1Institute of Anatomic Pathology, S. Maria del Carmine Hospital, Rovereto, Italy. Teresa.Pusiol@apss.tn.it

The American Journal of Dermatopathology
|November 2, 2011
PubMed
Summary
This summary is machine-generated.

This study reports the first case of a trichilemmal cyst with ossification, a rare finding in this common benign skin lesion. The bone formation may occur directly from stromal elements without cartilage.

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Area of Science:

  • Dermatopathology
  • Skeletal Biology

Background:

  • Trichilemmal cysts are common benign skin tumors.
  • Ossification is occasionally seen in cutaneous lesions.
  • The association between trichilemmal cysts and ossification has not been previously documented.

Observation:

  • A case of a 46-year-old woman with a trichilemmal cyst on her scalp is presented.
  • The cyst exhibited significant osseous metaplasia (bone formation).

Findings:

  • Microscopic examination revealed typical trichilemmal cyst features with intra- and extraluminal calcification.
  • Mature bone formation was observed, without evidence of cartilaginous precursors.
  • The ossification is hypothesized to be direct (membranous/mesenchymal) or dystrophic calcification-driven.

Implications:

  • This case expands the known spectrum of trichilemmal cyst pathology.
  • It highlights a rare instance of bone formation within a common cutaneous cyst.
  • Understanding the mechanism of ossification in this context may offer insights into bone development in soft tissues.