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Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
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Divergent synthetic approach to 6''-modified α-GalCer analogues
Nora Pauwels1, Sandrine Aspeslagh, Gerd Vanhoenacker
1Laboratory for Medicinal Chemistry (FFW), Faculty of Pharmaceutical Sciences, UGent, Harelbekestraat 72, B-9000 Gent, Belgium.
Organic & Biomolecular Chemistry
|November 2, 2011
Abstract:
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6''-modified KRN7000 analogues.
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