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Updated: May 28, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

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Published on: May 23, 2017

Transcallosal sensorimotor fiber tract structure-function relationships.

Brett W Fling1, Bryan L Benson, Rachael D Seidler

  • 1School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.

Human Brain Mapping
|November 2, 2011
PubMed
Summary
This summary is machine-generated.

The microstructure of white matter tracts connecting motor cortices is linked to the brain's ability to inhibit activity between hemispheres. Enhanced microstructure in these tracts predicts greater interhemispheric inhibition capacity in young adults.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Motor Control

Background:

  • Neuroanatomical studies reveal links between white matter microstructure, brain function, and task performance.
  • The microstructure of transcallosal motor fibers may indicate interhemispheric inhibition capacity between primary motor cortices, but this network requires further characterization.

Purpose of the Study:

  • To comprehensively describe transcallosal fibers connecting homologous sensorimotor cortical regions.
  • To determine the relationship between fiber tract microstructure and interhemispheric inhibition during voluntary cortical activity.

Main Methods:

  • Diffusion tensor imaging (DTI) was used to assess the microstructure of fiber tracts connecting homologous sensorimotor regions.
  • Interhemispheric inhibition was measured using the ipsilateral silent period (iSP) in the same participants.
  • A midsagittal callosal atlas in MNI space was created for future research on callosal fiber tracts.

Main Results:

  • Mutually exclusive transcallosal connections between homologous sensorimotor regions were mapped, with the densest connections found between medial motor areas.
  • A strong positive correlation (r = 0.76) was observed between the strength of interhemispheric inhibition (iSP) and the microstructure of transcallosal fibers connecting the primary motor cortices.
  • Increased fiber microstructure in young adults predicts enhanced interhemispheric inhibitory capacity.

Conclusions:

  • This study provides a detailed characterization of transcallosal sensorimotor networks.
  • Fiber tract microstructure, particularly in connections between primary motor cortices, is a significant predictor of interhemispheric inhibition.
  • Findings contribute to understanding the neurobiological basis of sensorimotor integration and interhemispheric communication.