Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 28, 2026

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Enabling biomedical research with designer quantum dots.

Nikodem Tomczak1, Dominik Jańczewski, Denis Dorokhin

  • 1Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore. tomczakn@imre.a-star.edu.sg

Methods in Molecular Biology (Clifton, N.J.)
|November 2, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emission of Photons by Near-Infrared PbS Quantum Dot Nanocrystals for a Large Diameter Range.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

Inorganic-biological hybrid cell factories for biogenic inorganic biomaterials and biohybrid biomanufacturing.

Biomaterials science·2026
Same author

Silk Fibroin-Templated Copper Nanoclusters: Responsive Fluorescent Probes Exhibiting 2,4-Dichlorophenoxyacetic Acid-Enhanced Emission and p-Nitrophenol-Induced Quenching.

Sensors (Basel, Switzerland)·2026
Same author

Chemical and enzymatic strategies for the synthesis, ligation, assembly and emerging applications of DNA nanostructures.

Biomaterials science·2026
Same author

Assembled Melamine-Regulated Synthesis of Uniform Manganese Dioxide Nanoribbons for Superior Heating Effect.

ACS applied materials & interfaces·2025
Same author

Phospholipid composition changes in bacterial membranes: A molecular mechanism of antibiotic resistance.

Advances in colloid and interface science·2025
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Quantum dots (QDs) are semiconductor nanoparticles for advanced bioimaging. Surface modifications enhance their water solubility, biocompatibility, and targeting capabilities for precise cellular and in vivo disease imaging.

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Quantum dots (QDs) are semiconductor nanoparticulate luminophores with emerging applications in biology and nanomedicine.
  • Their unique optical properties make them attractive for advanced imaging techniques.

Purpose of the Study:

  • To review recent advancements in the design and application of QD labels for cellular imaging.
  • To highlight the role of surface engineering in improving QD performance for biological applications.

Main Methods:

  • Surface chemical engineering to achieve water solubility and biocompatibility.
  • Functionalization with bioactive molecules (peptides, aptamers, antibodies) for targeted delivery.
  • Development of specialized surface coatings to minimize nonspecific interactions and cytotoxicity.

More Related Videos

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications
10:56

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Production and Targeting of Monovalent Quantum Dots
10:16

Production and Targeting of Monovalent Quantum Dots

Published on: October 23, 2014

Related Experiment Videos

Last Updated: May 28, 2026

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications
10:56

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Production and Targeting of Monovalent Quantum Dots
10:16

Production and Targeting of Monovalent Quantum Dots

Published on: October 23, 2014

Main Results:

  • Engineered QDs demonstrate improved water solubility, biocompatibility, and reduced toxicity.
  • Targeted QD probes enable specific imaging of living cells and disease states in vivo.
  • Advanced QD coatings enhance circulation lifetimes and minimize degradation under physiological conditions.
  • New QD probes show potential for single-molecule level imaging of cellular processes.

Conclusions:

  • Surface modification is crucial for developing effective QD-based imaging agents.
  • QDs offer significant potential for targeted in vitro and in vivo diagnostics.
  • QDs are integral to the development of sophisticated nanosystems for personalized medicine.