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Serotype Prevalence and Penicillin-susceptibility of Streptococcus pneumoniae in Oman

Mubarak M Al-Yaqoubi, Kamal M Elhag

    Oman Medical Journal
    |November 2, 2011
    PubMed
    Abstract

    Insights

    Prevalent Streptococcus pneumoniae serotypes in Oman include 9A, 6B, and 19F. Over half of pneumococcal strains show penicillin non-susceptibility, but most remain susceptible to ceftriaxone.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Streptococcus pneumoniae causes significant global disease burden.
    • Understanding pneumococcal serotype prevalence and antimicrobial resistance is crucial for public health strategies.

    Purpose of the Study:

    • To identify common Streptococcus pneumoniae serotypes in Oman.
    • To determine the rate of penicillin non-susceptibility among pneumococcal isolates in Oman.

    Main Methods:

    • Serotyping of pneumococcal isolates collected from September 2002 to December 2007 at the Royal Hospital, Oman.
    • Retrieved clinical data and penicillin susceptibility reports from hospital information systems and medical records.

    Main Results:

    • 120 Streptococcus pneumoniae strains were isolated; 85 were serotyped, revealing 20 distinct serotypes.
    • The most common serotypes identified were 9A, 6B, 19F, 14, and 23F.
    • 56% of strains exhibited penicillin non-susceptibility, with 99% remaining susceptible to ceftriaxone. Serotype coverage by PPV and PCV7 was 74.3% and 46.1%, respectively.

    Conclusions:

    • Specific pneumococcal serotypes (9A, 6B, 19F) are highly prevalent in the Omani population.
    • A significant proportion of Streptococcus pneumoniae isolates in Oman are non-susceptible to penicillin.
    • Ceftriaxone demonstrates high efficacy against the majority of identified pneumococcal strains.
    Keywords:
    Pneumococcal Serotypes Penicillin susceptibility in pneumocci.

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