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Silicone: a critical review.

D M Duffy1

  • 1University of California, Los Angeles.

Advances in Dermatology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Pure dimethypolysiloxane (DMPS) polymer, or liquid silicone, is safe for soft-tissue augmentation when used properly in appropriate volumes. While misuse led to bans, evidence suggests rare immunologically mediated adverse effects are possible even with correct application.

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Plastic Surgery

Background:

  • The biological response to implanted foreign materials is complex and variable.
  • Each implant type requires individual evaluation for specific applications and hosts.
  • Adverse reports on liquid silicone often stem from unknown purity, inappropriate volumes, or poor anatomical site selection.

Purpose of the Study:

  • To analyze the behavior and safety of pure dimethypolysiloxane (DMPS) polymer (liquid silicone) for soft-tissue augmentation.
  • To address the mistrust and unfounded bias against the proper use of liquid silicone.
  • To differentiate between misuse and the potential for rare adverse effects.

Main Methods:

  • Review of published anecdotal and personal experiences with 350 centistoke pure dimethypolysiloxane fluid.

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  • Analysis of case reports, considering purity, volume, anatomical site, and patient's health status.
  • Contextualization of reactions within broader tissue responses to foreign materials and autoimmune conditions.

    • Main Results:

    • Pure DMPS polymer exhibits specific behavior in subcutaneous tissues.
    • Most adverse events are linked to unknown fluids, excessive volumes, or unsuitable sites.
    • Rare immunologically mediated adverse effects, such as granulomatous reactions, can occur, potentially linked to infection or autoimmune conditions.

    Conclusions:

    • The advocates' position that liquid silicone is safe when used properly is supported by limited serious adverse reactions.
    • The potential for rare, immunologically mediated adverse effects, even with pure DMPS polymer, is irrefutable.
    • Bias against proper liquid silicone use is unfounded, but understanding potential adjuvant effects in susceptible individuals is crucial.