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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
Published on: January 2, 2013
Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols
Katayoun Saatchi1, Nikolaus Gelder, Pavel Gershkovich
1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
International Journal of Pharmaceutics
|November 3, 2011
Summary
A new gallium-67 labeled hyperbranched polyglycerol (HPGN) offers a stable, non-toxic blood pool imaging agent. Its long 50.7-hour half-life is ideal for diagnosing internal bleeding and potential PET imaging.
Area of Science:
- Biomedical Imaging
- Radiopharmaceutical Chemistry
- Macromolecular Science
Background:
- Current technetium-99m red blood cell agents pose handling risks and face supply shortages.
- There is a need for safe, synthetic alternatives for blood pool imaging and PET applications.
Purpose of the Study:
- To develop a long-circulating, biocompatible synthetic macromolecule for blood pool imaging.
- To evaluate a hyperbranched polyglycerol (HPG) derivative as a potential radiopharmaceutical.
Main Methods:
- A 500 kDa hyperbranched polyglycerol (HPG) was modified for gallium coordination.
- Radiolabeling efficiency, stability, and pharmacokinetics of the (67)Ga-HPGN were assessed.
- In vitro toxicity and hemocompatibility assays were performed.
Main Results:
- The (67)Ga-HPGN kit was rapidly labeled at room temperature and demonstrated stability.
- The agent was non-toxic in cell viability and hemocompatibility tests.
- Biodistribution studies confirmed blood pool confinement with a 50.7-hour biological half-life.
Conclusions:
- (67)Ga-HPGN is a simple-to-prepare blood pool imaging agent suitable for diagnosing internal bleeding.
- The potential for (68)Ga labeling suggests future applications in PET cardiac imaging.
