Related Experiment Video
Updated: Jan 16, 2026
09:02
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
Published on: September 27, 2024
3.1K
Drug delivery strategies for paediatric diffuse midline gliomas
Stefana Duca1, Sara Jamshidi Parvar2, Luke Kumeta3
1School of Pharmacy, Biodiscovery Institute, University of Nottingham, University Park, Nottingham NG7 2RD, UK; School of Pharmacy, Boots Science Building, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Advanced Drug Delivery Reviews
|September 27, 2025
Summary
Diffuse midline gliomas (DMGs) are aggressive pediatric brain tumors with poor prognosis. Novel drug delivery strategies are crucial for improving treatment access and patient outcomes.
Area of Science:
- Neuro-oncology
- Pediatric Oncology
- Drug Delivery Systems
Background:
- Diffuse midline gliomas (DMGs) represent a critical challenge in pediatric neuro-oncology due to their aggressive nature, inoperability, and poor median survival rates.
- Therapeutic advancements are significantly impeded by the tumor's location within the brainstem, substantial molecular heterogeneity, and the restrictive blood-brain barrier (BBB) that limits drug penetration.
Purpose of the Study:
- To review the current therapeutic strategies for diffuse midline gliomas.
- To evaluate emerging drug delivery methods aimed at enhancing therapeutic agent access to the brain for DMG treatment.
Main Methods:
- Exploration of the existing treatment landscape for DMGs.
- Evaluation of various drug delivery routes including oral, intravenous, intrathecal, intranasal administration, and convection-enhanced delivery (CED).
Main Results:
- The anatomical location and molecular complexity of DMGs pose significant therapeutic hurdles.
- Emerging drug delivery strategies show promise in overcoming the BBB and improving drug distribution within the brain.
Conclusions:
- Advancements in drug delivery, such as CED and intranasal approaches, are vital for improving DMG treatment efficacy.
- Combining enhanced drug delivery with targeted therapies offers a promising avenue for improving clinical outcomes in pediatric patients with diffuse midline gliomas.
Related Concept Videos
01:29Drug Delivery: Parenteral Route
1.5K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.5K
01:22Drug Delivery: Miscellaneous Routes
713
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
713
01:16Drug Delivery: Overview
724
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
724
01:18Drug Delivery: Enteral Route
1.6K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.6K
01:18Additional Routes of Drug Administration
4.6K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
4.6K