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Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol

Wan-hua Yang1, Hong-bin Gu, Bing Chen

  • 1Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. yangwanhuaywh@sina.com

Journal of Translational Medicine
|November 3, 2011
PubMed

Insights

The SLOG/TCI-III system for propofol infusion in children shows acceptable performance. This target-controlled infusion system demonstrated a median performance error (MDPE) of 10% and median absolute performance error (MDAPE) of 22%.

Area of Science:

  • Anesthesiology
  • Pharmacokinetics
  • Pediatric Medicine

Background:

  • The SLOG/TCI-III system is a target-controlled infusion model adapted for pediatric propofol administration.
  • Previous models were based on local pediatric populations.

Purpose of the Study:

  • To evaluate the performance of the SLOG/TCI-III system in children.
  • To assess the accuracy of propofol concentration measurements against target concentrations.

Main Methods:

  • Thirty pediatric patients (ASA I-II) were studied.
  • Propofol target plasma concentrations were entered into the SLOG/TCI-III system.
  • Measured propofol concentrations were analyzed using high-performance liquid chromatography with fluorescence detection.
  • Performance error (PE), median performance error (MDPE), median absolute performance error (MDAPE), and Wobble were calculated.

Main Results:

  • A strong linear correlation was observed between measured and target propofol concentrations (r = 0.8667).
  • The pediatric system achieved an MDPE of 10% and an MDAPE of 22%.
  • The median Wobble was 24%.

Conclusions:

  • The SLOG/TCI-III system demonstrates performance within accepted clinical practice limits for pediatric anesthesia.
  • The system's accuracy supports its use in pediatric target-controlled propofol infusion.
Abstract

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