Related Experiment Video
Updated: May 28, 2026

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
Published on: May 2, 2019
Complexation and conjugation approaches to evaluate siRNA delivery using cationic, hydrophobic and amphiphilic
Jung Woo Park1, Eun-Kyoung Bang, Eun Mi Jeon
1Department of Chemistry, Division of IBB, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
Abstract:
In this study, we used solid phase synthesis to prepare three kinds of peptides and then formulated their peptide-siRNA complexes and peptide-siRNA conjugates. Both the complexation and conjugation systems were nontoxic and allowed the delivery of siRNA into the cytoplasm without the need for any transfection agents and with subsequent inhibition of gene expression.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Site-Targeted

