Primary cutaneous large B-cell lymphoma, leg type

Area of Science:

• Dermatology
• Hematology
• Oncology

Background:

• Primary cutaneous large B-cell lymphoma, leg type (PCLBCL-LT) is a rare and aggressive non-Hodgkin lymphoma.
• The World Health Organization-European Organization for Research and Treatment of Cancer classification defines PCLBCL-LT.
• Cutaneous lymphomas represent a diverse group of extranodal non-Hodgkin lymphomas.

Purpose of the Study:

• To present a case of PCLBCL-LT on the forearm.
• To review the clinical features and management of PCLBCL-LT.
• To contribute to the understanding of this rare lymphoma subtype.

Main Methods:

• Case presentation of a 74-year-old female with a forearm cutaneous lesion.
• Skin biopsy for histopathological diagnosis.
• Systemic chemotherapy regimen: rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisone.
• Literature review of PCLBCL-LT.

Main Results:

• Histopathology confirmed PCLBCL-LT.
• The patient received combined immunochemotherapy.
• Literature review summarized key clinical and management aspects.

Conclusions:

• PCLBCL-LT, though rare, requires prompt diagnosis and treatment.
• Combined immunochemotherapy is a viable treatment option.
• Further research into optimal management strategies for PCLBCL-LT is warranted.