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Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome
Sangita U Sawant1, Subhash Chandran, Alan F Almeida
1Radiation Medicine Centre, Bio-Medical Group, Bhabha Atomic Research Centre (BARC), Tata Memorial Hospital Annexe Building, Parel, Mumbai 400 012, India.
International Journal of Nephrology
|November 3, 2011
Summary
Nephrotic syndrome patients experience altered thyroid function due to protein and thyroid hormone loss in urine. This thyroid dysfunction is reversible upon remission of the nephrotic syndrome.
Area of Science:
- Nephrology
- Endocrinology
- Biochemistry
Background:
- Nephrotic syndrome involves significant protein loss in urine, a characteristic of chronic kidney disease.
- The study investigates the potential link between oxidative stress and thyroid function in nephrotic patients.
Purpose of the Study:
- To determine the correlation between oxidative stress markers and thyroid function in nephrotic syndrome patients.
- To assess if urinary loss of thyroid hormones contributes to altered thyroid status.
Main Methods:
- Compared 60 nephrotic syndrome patients with 20 healthy controls.
- Measured serum thyroid hormones (TT4, TT3, TSH) and oxidative stress markers (LPx, catalase, SOD, GPx).
Main Results:
- Nephrotic patients showed elevated TSH and lower TT4/TT3 levels compared to controls.
- Increased lipid peroxidation and Glutathione peroxidase, with decreased Superoxide dismutase and catalase, were observed in patients.
Conclusions:
- Urinary protein loss in nephrotic syndrome can lead to significant thyroid hormone excretion, impacting thyroid status.
- The observed thyroid dysfunction is reversible upon remission of the nephrotic syndrome.
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