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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Diffusion tensor imaging of the median nerve: intra-, inter-reader agreement, and agreement between two software
Roman Guggenberger1, Daniel Nanz, Gilbert Puippe
1Musculoskeletal Imaging Research Group, Department of Radiology, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland.
Skeletal Radiology
|November 4, 2011
Summary
Magnetic resonance diffusion tensor imaging (DTI) of the median nerve shows good intra-reader agreement. Inter-reader and software agreement were moderate, indicating minimal user and software influence on DTI measurements.
Area of Science:
- Neuroimaging
- Medical Physics
Background:
- Diffusion Tensor Imaging (DTI) is a valuable MRI technique for assessing white matter integrity.
- Median nerve assessment is crucial for diagnosing neuropathies, but DTI reliability requires evaluation.
Purpose of the Study:
- To evaluate the reliability of DTI measurements of the median nerve.
- To assess intra-reader, inter-reader, and software agreement for DTI metrics.
Main Methods:
- Fifteen healthy volunteers underwent 1.5T wrist DTI.
- Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured by three readers using two software packages.
- Intraclass correlation coefficients (ICC) and Bland-Altman analysis were used.
Main Results:
- High intra-reader agreement (ICC: 0.87–0.99).
- Moderate inter-reader agreement (ICC: 0.62–0.83) and software agreement (ICC: 0.63–0.82).
- Bland-Altman analysis confirmed no significant differences.
Conclusions:
- DTI measurements of the median nerve demonstrate good intra-reader reliability.
- Moderate inter-reader and software agreement suggest minimal user and software variability.
- DTI is a reliable tool for median nerve assessment.
