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Updated: May 27, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Epigenetics of nicotine: another nail in the coughing
1National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov
Abstract:
In a mouse model, chronic nicotine exposure before cocaine use exacerbated the epigenetic, gene-expression, electrophysiological, and behavioral effects that occur during the transition from acute to chronic responses to cocaine that have been linked with the addictive process. Nicotine enhancement of the effects can be mimicked with an inhibitor of chromatin-modifying enzymes (class I and II histone deacetylases). These findings may spur the discovery of therapeutics for the treatment of addiction.
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