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Updated: May 27, 2026
11:52
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Silver distribution and release from an antimicrobial denture base resin containing silver colloidal nanoparticles
Douglas Roberto Monteiro1, Luiz Fernando Gorup, Aline Satie Takamiya
1Department of Dental Materials and Prosthodontics, Araçatuba Dental School, Univ Estadual Paulista, Brazil Federal University of São Carlos-Exact Science and Technology Center, Brazil.
Summary
Silver nanoparticles were incorporated into denture base resin. No silver was detected leaching into water, suggesting a safe, potentially antimicrobial material for denture wearers.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Nanotechnology
Background:
- Denture-related infections are common in complete denture wearers.
- Silver nanoparticles (AgNPs) show antimicrobial properties.
- Incorporating AgNPs into denture base resins could offer a solution.
Purpose of the Study:
- To evaluate the distribution and dispersion of silver colloidal nanoparticles within a denture base resin.
- To assess the silver ion release from the nanocomposite resin over time.
Main Methods:
- Silver nanoparticles were synthesized and added to Lucitone 550 denture resin at varying concentrations (0.05, 0.5, 5 vol%).
- Specimens were stored in deionized water at 37°C for up to 120 days.
- Silver release was quantified using atomic absorption spectroscopy; morphology was analyzed via micrographs.
Main Results:
- Silver was not detected in the deionized water, even after 120 days.
- Nanoparticle distribution decreased with lower concentrations, while dispersion improved.
- After 120 days, nanoparticles were predominantly found on the surface of the nanocomposite.
Conclusions:
- Silver nanoparticles were successfully incorporated into the polymethyl methacrylate (PMMA) denture resin.
- No silver leaching was detected within the study's detection limits.
- This AgNP-reinforced PMMA resin holds potential as an antimicrobial material for complete denture wearers.
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