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Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
Published on: February 11, 2017
[Increased survival rates of children with cystic fibrosis]
C Vázquez Cordero1, G Idígoras Ayastuy, M S Galardi Andonegui
1Hospital Infantil de Cruces, Cruces-Baracaldo, Vizcaya.
Insights
Survival rates for cystic fibrosis (CF) patients significantly improved between 1972 and 1988. Closer follow-up and aggressive treatment in CF care led to better outcomes.
Area of Science:
- Medical Research
- Pediatrics
- Pulmonology
Context:
- Retrospective analysis of cystic fibrosis (CF) patient data from 1972 to 1989.
- Involves a cohort of 75 patients under continuous care.
- Examines survival trends over two distinct periods: 1972-1980 and 1981-1988.
Purpose:
- To evaluate the progress and changes in survival rates for cystic fibrosis patients.
- To compare mortality and survival outcomes between two defined treatment periods.
- To identify factors contributing to observed changes in patient survival.
Summary:
- A significant decrease in mortality was observed in the later period (14% vs. 57%, p < 0.001).
- Cumulative survival rates at ages 1, 5, and 10 years showed remarkable increases in the second period.
- Patient survival improved from 28 under care in 1972 to 50 in 1989.
Impact:
- Suggests that increased clinical experience, diligent follow-up, and aggressive therapeutic strategies enhance CF patient survival.
- Highlights the critical need for establishing specialized cystic fibrosis centers for optimal disease management.
- Provides evidence for improved outcomes in cystic fibrosis care through dedicated management approaches.
Abstract:
Seventy-two patients with cystic fibrosis were under care between January 1st 1972 and December 31st 1988, and 75 until now (July 1989). Fifty are alive, 24 died and 1 was lost to follow-up. The number of alive patients under control at the end of every year rose from 5 in 1972 up to 47 in 1988 and 50 at present. In order to assess the progress of survival rates, we compared two periods: 1972-1980 and 1981-1988. Twenty-eight were under control during the first period and 16 (57%) died, these figures for the second period being 55 and 8 (14%) (p 0.001) respectively. A remarkable increase in cumulative survival rates during the second period was observed at ages 1 (96% vs 68%), 5 (94% vs 55%) and 10 (86% vs 28%). Greater experience and closer follow-up, together with more aggressive treatment are likely to account for the increase in survival. It is vital that reference cystic fibrosis centers should be set-up in our country for the management of so complex a disease as 'cystic fibrosis.
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