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Related Experiment Video

Updated: May 27, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

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Published on: July 8, 2025

Polymorphic form IV of olanzapine.

Ranjit Thakuria¹, Ashwini Nangia

¹School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.

Acta Crystallographica. Section C, Crystal Structure Communications

|November 5, 2011

Summary

A new crystal form (Form IV) of olanzapine, a psychotropic drug, was discovered. This thienobenzodiazepine exhibits unique dimer arrangements stabilized by specific molecular interactions.

Area of Science:

Crystallography
Solid-state chemistry
Pharmacology

Background:

Olanzapine (2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine) is a key psychotropic agent in the thienobenzodiazepine class.
Understanding olanzapine's solid-state forms is crucial for its pharmaceutical development and efficacy.

Purpose of the Study:

To investigate the formation and structural characteristics of a novel polymorph of olanzapine.
To elucidate the intermolecular interactions governing the crystal packing of this new form.

Main Methods:

Attempted cocrystallization of olanzapine with nicotinamide in an ethyl acetate solution.
Single-crystal X-ray diffraction analysis to determine the crystal structure.

Main Results:

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Published on: July 8, 2025

A new polymorph, designated Form IV, was successfully obtained.
Form IV features centrosymmetric dimers of olanzapine molecules stabilized by C-H···π interactions.
The crystal structure of Form IV exhibits a herringbone arrangement of these dimers, distinct from the parallel arrangement in Form II.
Both forms are stabilized by N-H···N hydrogen bonds.

Conclusions:

The study successfully identified and characterized a new polymorph (Form IV) of olanzapine.
The findings highlight the role of weak interactions (C-H···π) and hydrogen bonding in dictating the crystal architecture of thienobenzodiazepines.
This research contributes to the understanding of olanzapine's solid-state properties, potentially impacting formulation and drug delivery.