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A novel treatment for ulcerative calcinosis cutis
1Saint Joseph Mercy Health System, Dermatology Residency Program, Ann Arbor, MI, USA. brookebair@gmail.com
Journal of Drugs in Dermatology : JDD
|November 5, 2011
Summary
Topical 25% sodium thiosulfate effectively treated two cases of ulcerative calcinosis cutis unresponsive to other therapies. This compound shows promise as an alternative treatment for dystrophic calcinosis cutis.
Area of Science:
- Dermatology
- Nephrology
- Calcium Metabolism Disorders
Background:
- Calcinosis cutis encompasses disorders characterized by calcium deposits in the skin, categorized by etiology.
- Calciphylaxis, a severe form of calcinosis cutis, has been systemically treated with sodium thiosulfate with minimal adverse effects.
Observation:
- Two patients presented with ulcerative calcinosis cutis refractory to multiple topical treatments.
- These cases did not improve despite correction of underlying electrolyte abnormalities.
Findings:
- Both patients demonstrated an excellent response to topical 25% sodium thiosulfate compounded in zinc oxide.
- This suggests efficacy in treating dystrophic calcinosis cutis.
Implications:
- Topical sodium thiosulfate 25% presents a potential alternative treatment for recalcitrant dystrophic calcinosis cutis.
- Further research with larger sample sizes is warranted to confirm these findings.
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