Related Experiment Video
Updated: May 27, 2026
05:39
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
Primary IgA nephropathy in north India: is it different?
Neha Mittal1, Kusum Joshi, Swapnil Rane
1Department of Histopathology, Post-graduate Institute of Medical Education & Research, Chandigarh, India.
Postgraduate Medical Journal
|November 5, 2011
Summary
Immunoglobulin A (IgA) nephropathy presents as advanced kidney disease in younger Indian adults. Further research into underlying factors is crucial for effective treatment strategies.
Area of Science:
- Nephrology
- Pathology
- Immunology
Background:
- Immunoglobulin A (IgA) nephropathy is a common global kidney disease, with a significant burden in Asian countries.
- Its prevalence and clinical characteristics in India remain under-documented.
Purpose of the Study:
- To investigate the clinicopathologic spectrum of primary IgA nephropathy in India.
- To compare findings with international and national data.
Main Methods:
- A cross-sectional study of 66 patients with IgA nephropathy over two years.
- Analysis of renal biopsy findings, clinical features, and classification using Haas and Oxford (MEST) systems.
- Immunofluorescence and electron microscopy were employed.
Main Results:
- IgA nephropathy accounted for 8.1% of native kidney biopsies.
- Patients presented younger (mean age 29.9 years) with advanced disease (62% Haas class V).
- Renal failure and nephrotic proteinuria were common; proliferative lesions correlated with higher creatinine.
Conclusions:
- IgA nephropathy in India presents with more advanced pathology in younger patients compared to other regions.
- Identifying etiological factors could lead to significant therapeutic advancements.
Related Concept Videos
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:29Acute Kidney Injury II: Pathophysiology
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:27Acute Pyelonephritis I: Introduction
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...