Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conditional Reactivation of Lysozyme Nanosystems via Hydrophobic Ion Pairing.

ACS nanoscience Au·2026
Same author

Multitargeted nanoparticles inhibit cancer invasion by disrupting cancer-associated fibroblast-tumor cell crosstalk and modulating collagen pattern and EMT.

Journal of nanobiotechnology·2026
Same author

Towards targeted drugs and next generation of nanomedicines.

Beilstein journal of nanotechnology·2026
Same author

Uptake of Nanoparticles as a Model System for Viruses under the Presence of Chloroquine.

ACS nanoscience Au·2026
Same author

Advances in fluorescence-based point-of-care diagnostics: probes, nanostructures and integrated systems.

Journal of materials chemistry. C·2026
Same author

Peer Review and AI: Your (Human) Opinion Is What Matters.

ACS nano·2026

Related Experiment Video

Updated: May 27, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Multiplexed sensing of ions with barcoded polyelectrolyte capsules.

Loretta L del Mercato1, Azhar Z Abbasi, Markus Ochs

  • 1Fachbereich Physik and WZMW, Philipps Universität Marburg, Marburg, Germany.

ACS Nano
|November 8, 2011
PubMed
Summary

Double-wall sensor capsules enable multiplexed detection of multiple analytes, overcoming limitations of current optical sensors. This innovation allows for parallel quantitative analysis of ions like proton, sodium, and potassium.

More Related Videos

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples
08:18

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

Related Experiment Videos

Last Updated: May 27, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples
08:18

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Multiplexed analyte detection is crucial for medical and biochemical applications but faces technical challenges like emission crosstalk in current optical sensors.
  • Fluorescent particulate devices are being developed as ratiometric optical sensors for intracellular analyte concentration measurement, relying on emission intensity changes of entrapped probes.

Purpose of the Study:

  • To demonstrate the efficacy of double-wall barcoded sensor capsules for multiplexed analysis of proton, sodium, and potassium ions.
  • To overcome the technical limitations of existing sensors that hinder parallel quantitative detection of multiple analytes.

Main Methods:

  • Development of porous microcapsules containing ion-sensitive probes for analyte detection within their inner cavity.
  • Engineering of unique quantum dot (QD) barcodes onto the outermost capsule wall for individual sensor identification.
  • Utilizing changes in probe emission intensity, modulated by ion concentration, for ratiometric optical sensing.

Main Results:

  • Successful multiplexed analysis of proton, sodium, and potassium ions using the developed sensor capsules.
  • Demonstration that QD barcodes on capsule walls enable unique identification of individual sensors.
  • Overcoming emission crosstalk issues inherent in previous multiplexed sensor designs.

Conclusions:

  • Double-wall barcoded sensor capsules offer a promising strategy for optical multianalyte determination.
  • This approach enhances the capability for quantitative, parallel detection of various ions in complex biological samples.
  • The integration of QD barcodes with sensor capsules represents a significant advancement in multiplexed sensing technology.