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Updated: May 27, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Notable increase in the consumption of antibiotics in general practice]
Ulrich Stab Jensen1, Lars Bjerrum
1Afdeling for Mikrobiologisk Overvågning og Forskning, Statens Serum Institut, Ørestads Boulevard 5, 2300 København S, Denmark. uje@ssi.dk
Abstract:
The antimicrobial consumption in primary health care has increased notably during the latest decade. The increase has predominantly been among broad-spectrum antimicrobial agents. Denmark is no longer among the European countries with the lowest consumption. The reasons for these changes are not fully explained, but increased dosage for each treated patient and more patients treated have played an important role. To some extent, the consumption meets with relevant quality indicators for antibiotic prescribing, but the use of resistance inducing antibiotics needs to be limited according to guidelines.
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