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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...

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Related Experiment Video

Updated: May 27, 2026

Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Notch and inflammatory T-cell response: new developments and challenges.

Kazuhiro Mochizuki1, Shan He, Yi Zhang

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5942, USA.

Immunotherapy
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

Notch signaling is crucial for regulating T-cell responses. Modulating Notch offers potential therapeutic benefits for inflammatory diseases by controlling effector T cells.

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • T-cell mediated inflammation is vital for host defense against pathogens and cancer.
  • Dysregulated effector T cells can lead to inflammatory disorders like autoimmune diseases and graft-versus-host disease.
  • Precise control of effector T cell differentiation is essential for maintaining immune homeostasis.

Purpose of the Study:

  • To elucidate the role of Notch signaling in regulating effector T cell differentiation.
  • To explore the therapeutic potential of modulating Notch in inflammatory conditions.

Main Methods:

  • Review of recent scientific literature on Notch signaling and T-cell immunology.
  • Analysis of studies investigating Notch pathway involvement in effector T cell development.
  • Examination of therapeutic strategies targeting Notch for inflammatory disease treatment.

Main Results:

  • Notch signaling critically influences the differentiation of antigen-activated T cells into specific effector lineages.
  • Modulation of Notch pathways has demonstrated beneficial effects in preclinical models of inflammatory diseases.
  • Targeting Notch presents a promising avenue for managing immune-related disorders.

Conclusions:

  • Notch signaling is a key regulator of effector T cell fate and function.
  • Targeting the Notch pathway holds significant therapeutic promise for treating a range of inflammatory diseases.
  • Further research into Notch modulation could lead to novel treatments for immune dysregulation.