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Related Experiment Video

Updated: May 27, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

New algorithm for OHSS prevention.

Evangelos G Papanikolaou1, Peter Humaidan, Nikos Polyzos

  • 1Human Reproduction & Genetics Foundation, Adrianoupoleos 6, 55133 Kalamaria, Thessaloniki, Greece. drvagpapanikolaou@yahoo.gr

Reproductive Biology and Endocrinology : RB&E
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

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New strategies combining GnRH antagonist protocols, GnRH agonist triggering, blastocyst transfer, and embryo/oocyte vitrification can eliminate Ovarian Hyperstimulation Syndrome (OHSS) risk in IVF. This approach aims to prevent OHSS, a serious complication of fertility treatments.

Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization (IVF)

Background:

  • Ovarian Hyperstimulation Syndrome (OHSS) is a life-threatening complication of IVF.
  • OHSS deters patients, particularly those with prior experience, from pursuing fertility treatments and childbearing.

Purpose of the Study:

  • To present an algorithm for eliminating OHSS in IVF patients undergoing ovarian hyperstimulation.
  • To detail decision-making points and protocols to mitigate OHSS risk.

Main Methods:

  • Implementation of four key modalities: GnRH antagonist protocol, GnRH agonist (GnRHa) triggering, blastocyst transfer, and embryo/oocyte vitrification.
  • An algorithm based on follicle count (≥18 follicles) and decision points at specific days post-ovarian stimulation and oocyte pick-up (OPU).
  • Options include hCG triggering with freeze-all or day-5 transfer/vitrification, or GnRHa triggering with day-5 transfer/vitrification or early embryo freezing.

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Last Updated: May 27, 2026

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Main Results:

  • The combined use of GnRH antagonist protocol with GnRHa triggering and subsequent single blastocyst transfer or embryo/oocyte freezing can abolish the risk of OHSS.
  • While hCG triggering with freeze-all or day-5 strategies can reduce risk, they do not guarantee an OHSS-free luteal phase, especially if pregnancy occurs.

Conclusions:

  • The proposed algorithm and combined modalities offer a pathway to eliminate OHSS in IVF.
  • Future widespread adoption of GnRHa triggering and oocyte vitrification is anticipated to further enhance OHSS prevention.