Diversity-oriented optical imaging probe development
Jun-Seok Lee1, Marc Vendrell, Young-Tae Chang
1Biomolecules Function Research Center, Future Convergence Research Division, Korea Institute of Science and Technology, 136-791, South Korea.
Abstract:
The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.
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