Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cervical Multifidus Fatty Degeneration and Bony Foraminal Stenosis Are Associated with Unsuccessful Response to Stellate Ganglion Block in Cervical Radicular Pain: A Retrospective Study.

Medicina (Kaunas, Lithuania)·2026
Same author

Functional Ureteral Obstruction Due to Retroperitoneal Tissue Interposition During Oblique Lumbar Interbody Fusion: A Report of Two Cases.

Journal of clinical medicine·2026
Same author

Risk Factors for the Occurrence of Femoral Fractures in Inflammatory Bowel Disease Patients: A Nationwide Population-Based Cohort Study.

Journal of clinical medicine·2026
Same author

Lifetime chemical sensor arrays of organic fluorophores for bacterial fingerprinting.

Nature communications·2026
Same author

Deep learning magnetic resonance imaging algorithm for differentiating metastatic vertebral fractures.

The spine journal : official journal of the North American Spine Society·2026
Same author

A platform to design and optimise fluorogenic scFvs for detection of interleukin 33.

Chemical science·2026
Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026
Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026
Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026
Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026
Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026
Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026
See all related articles

Related Experiment Video

Updated: May 27, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
09:56

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Diversity-oriented optical imaging probe development.

Jun-Seok Lee1, Marc Vendrell, Young-Tae Chang

  • 1Biomolecules Function Research Center, Future Convergence Research Division, Korea Institute of Science and Technology, 136-791, South Korea.

Current Opinion in Chemical Biology
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

Diversity-driven strategies accelerate the discovery of novel optical probes for medical imaging and diagnostics. These methods enhance probe variety, leading to improved molecular affinity, cellular selectivity, and sensitivity for advanced applications.

More Related Videos

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
10:35

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales
09:56

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales

Published on: August 21, 2019

Related Experiment Videos

Last Updated: May 27, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
09:56

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
10:35

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales
09:56

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales

Published on: August 21, 2019

Area of Science:

  • Chemistry
  • Biotechnology
  • Medical Imaging

Background:

  • Optical probes are increasingly vital for diagnostics and medical imaging.
  • Developing probes with specific properties like high sensitivity and photostability is crucial.

Purpose of the Study:

  • To review diversity-driven strategies for discovering new molecular imaging probes.
  • To highlight how these approaches enrich probe variety and identify key characteristics.

Main Methods:

  • Utilizing combinatorial chemistry and high-throughput screening.
  • Employing diversity-oriented approaches to generate a wide range of probe candidates.
  • Analyzing probe properties such as molecular affinity and cellular selectivity.

Main Results:

  • Successful identification of novel molecular imaging probes through diversity-driven strategies.
  • Demonstration of enhanced spectral and structural variety in discovered probes.
  • Validation of specific properties like high photostability and sensitivity in new probes.

Conclusions:

  • Diversity-driven strategies are effective for discovering advanced optical probes.
  • These methods significantly contribute to the development of next-generation diagnostic and imaging agents.
  • The review showcases the power of combinatorial approaches in molecular probe development.