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Postnatal neurogenesis in the human forebrain: from two migratory streams to dribbles

Zhengang Yang1, Guo-li Ming, Hongjun Song

  • 1Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China. yangz@fudan.edu.cn

Cell Stem Cell
|November 8, 2011
PubMed
Abstract

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...