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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
Published on: December 14, 2017
Cognitive dysfunction in Tunisian LRRK2 associated Parkinson's disease
Samia Ben Sassi1, Fatma Nabli, Emna Hentati
1Neurology Department, National Institute of Neurology, La Rabta-1007, Tunis, Tunisia. bensassisam@yahoo.fr
Parkinsonism & Related Disorders
|November 8, 2011
Summary
Cognitive impairment in Parkinson's disease (PD) patients with and without the LRRK2 G2019S mutation showed similar patterns, primarily affecting visuospatial and executive functions. Further studies are needed to confirm these findings.
Area of Science:
- Neurology
- Genetics
- Cognitive Science
Background:
- Cognitive impairment and dementia are common in Parkinson's disease (PD).
- The specific cognitive profile in LRRK2-associated PD is not well-established.
- LRRK2 (leucine-rich kinase 2) mutations are a significant genetic factor in PD.
Purpose of the Study:
- To evaluate and compare cognitive function in PD patients with and without the LRRK2 G2019S mutation.
- To identify patterns of cognitive deficits in LRRK2-associated PD.
Main Methods:
- A cohort of 55 PD patients with the LRRK2 G2019S mutation was compared to 55 non-carriers.
- Cognitive assessments included Mini-Mental Examination (MMSE), Montreal Cognitive Assessment (MOCA), and Frontal Assessment Battery (FAB).
- Clinical data including motor severity (MDS-UPDRS, Hoehn and Yahr) and depression (GDS) were collected.
Main Results:
- Cognitive performance (MMSE, MOCA, FAB) was similar between LRRK2 G2019S carriers and non-carriers.
- Both groups exhibited impairments in visuospatial and executive functions.
- Cognitive decline correlated with older age, lower education, and greater motor impairment severity.
Conclusions:
- PD patients with and without the LRRK2 G2019S mutation demonstrate comparable cognitive function.
- Visuospatial and executive domains are predominantly affected in both groups.
- Larger, prospective studies are recommended for validation.
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