Related Experiment Video
Updated: May 27, 2026
Studying Murine Small Bowel Mechanosensing of Luminal Particulates
Published on: March 18, 2022
Biomechanical testing and material characterization for the rat large intestine: regional dependence of material
Dimitrios P Sokolis1, Ioannis K Orfanidis, Michalis Peroulis
1Laboratory of Biomechanics, Foundation of Biomedical Research, Academy of Athens, Athens, Greece. DimitrisSokolis@ath.forthnet.gr
Abstract:
The function of the large bowel is to absorb water from the remaining indigestible food matter and subsequently pass useless waste material from the body, but there has been only a small amount of data in the literature on its biomechanical characteristics that would facilitate our understanding of its transport function. Our study aims to fill this gap by affording comprehensive inflation/extension data of intestinal segments from distinct areas, spanning a physiologically relevant deformation range (100-130% axial stretches and 0-15 mmHg lumen pressures). These data were characterized by the Fung-type exponential model in the thick-walled setting, showing reasonable agreement, i.e. root-mean-square error ~30%. Based on optimized material parameters, i.e. a(1)
