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AURA: Atlas of UTR Regulatory Activity
1Laboratory of Translational Genomics - Centre for Integrative Biology, University of Trento, Via delle Regole, 101, 38123 Mattarello (TN), Italy.
Bioinformatics (Oxford, England)
|November 8, 2011
Summary
The Atlas of UTR Regulatory Activity (AURA) provides a comprehensive catalog of human mRNA untranslated regions (UTRs) and their regulatory annotations. This resource integrates diverse data for UTR research.
Area of Science:
- Genomics
- Bioinformatics
- Molecular Biology
Background:
- Untranslated regions (UTRs) of messenger RNA (mRNA) play critical roles in gene regulation.
- Comprehensive databases are needed to consolidate information on UTRs and their regulatory elements.
Purpose of the Study:
- To present the Atlas of UTR Regulatory Activity (AURA), a manually curated resource for human mRNA UTRs.
- To provide a centralized platform for accessing diverse UTR-related data.
Main Methods:
- Manual curation of human mRNA UTR sequences and regulatory annotations.
- Integration of data from various sources including phylogenetic conservation, RNA structure, and genetic variation.
- Development of an intuitive web interface for data access.
Main Results:
- AURA offers a comprehensive catalog of human mRNA UTRs.
- The database integrates phylogenetic conservation, RNA sequence and structure, single nucleotide variation, and gene expression data.
- Functional descriptions from literature and specialized databases are included.
Conclusions:
- AURA serves as a valuable resource for researchers studying UTRs and their regulatory functions.
- The integrated data facilitates a deeper understanding of post-transcriptional gene regulation.
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