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Updated: May 27, 2026

Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement
Published on: September 18, 2021
Cholinergic modulation of a specific memory function of prefrontal cortex
Paula L Croxson1, Diana A Kyriazis, Mark G Baxter
1Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute, Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.
Abstract:
Deficits in prefrontal cholinergic function are implicated in cognitive impairment in many neuropsychiatric diseases, but acetylcholine's specific role remains elusive. Rhesus monkeys with selective lesions of cholinergic input to prefrontal cortex (PFC) were unimpaired in tests of decision making and episodic memory that require intact PFC, but were severely impaired on a spatial working memory task. These observations are consistent with a specific role for prefrontal acetylcholine in working memory.
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