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Updated: May 27, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis and diabetes: a two-way relationship
P M Preshaw1, A L Alba, D Herrera
1School of Dental Sciences and Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK. p.m.preshaw@ncl.ac.uk
Diabetologia
|November 8, 2011
Summary
Diabetes significantly increases periodontitis risk and severity. Treating periodontal disease in diabetics improves glycemic control and reduces risks of kidney disease and cardiovascular mortality.
Area of Science:
- Oral Health
- Endocrinology
- Immunology
Background:
- Periodontitis is a prevalent chronic inflammatory disease affecting tooth-supporting structures.
- Diabetes is a major risk factor for periodontitis, with a threefold increased susceptibility.
- A bidirectional relationship exists between periodontitis and diabetes, impacting glycemic control and disease severity.
Purpose of the Study:
- To elucidate the intricate relationship between periodontitis and diabetes.
- To highlight the impact of periodontal inflammation on glycemic control and diabetes complications.
- To emphasize the importance of oral health in diabetes management.
Main Methods:
- Review of epidemiological data linking diabetes and periodontitis.
- Analysis of mechanisms involving immune function, neutrophils, and cytokines.
- Assessment of outcomes related to glycemic control and diabetes-related complications.
Main Results:
- Increased risk and severity of periodontitis in individuals with diabetes, correlated with hyperglycemia.
- Periodontal inflammation negatively affects glycemic control (HbA1c).
- Diabetic individuals with severe periodontitis show increased risks of macroalbuminuria, end-stage renal disease, and cardiorenal mortality.
Conclusions:
- Oral and periodontal health are critical components of comprehensive diabetes management.
- Treating periodontitis in diabetic patients can lead to significant improvements in glycemic control (approx. 0.4% HbA1c reduction).
- Addressing periodontal disease may mitigate severe diabetes complications, including renal and cardiovascular issues.
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