Related Experiment Video
Updated: May 27, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray
1Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, FL, USA. mddisney@buffalo.edu
Abstract:
Widespread bacterial resistance to antibiotics is a significant public health concern. To remain a step ahead of evolving bacteria, new methods to study resistance to antibacterials and to uncover novel antibiotics that evade resistance are urgently needed. Herein, microarray-based methods that have been developed to study aminoglycoside modification by resistance-causing enzymes are reviewed. These arrays can also be used to study the binding of aminoglycoside antibiotics to a mimic of their therapeutic target, the rRNA aminoacyl site (A-site), and how modification by resistance-causing enzymes affects their abilities to bind RNA.
More Related Videos
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
05:06Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
Published on: January 5, 2024
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Mechanism of Antibiotic Resistance in MRSA
Development of Antibiotic Resistance
Gene Regulation in Microbial Communities: Quorum Sensing