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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
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Depression in wilson's disease.

R S Pandey1, H S Swamy, K N Sreenivas

  • 1Lecturer in Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore-560029.

Indian Journal of Psychiatry
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

Wilson's Disease often presents with psychiatric symptoms, most commonly depression. Severity of depression correlates with the extent of neurological impairment in patients with this rare genetic disorder.

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Area of Science:

  • Neurology
  • Psychiatry
  • Genetics

Background:

  • Wilson's Disease is a rare genetic disorder causing copper accumulation.
  • Neurological and psychiatric manifestations are common in Wilson's Disease.

Purpose of the Study:

  • To investigate the prevalence and nature of psychiatric symptoms in patients with Wilson's Disease.
  • To explore the relationship between psychiatric symptoms and neurological features.

Main Methods:

  • A cohort of 23 Wilson's Disease patients were individually assessed by a psychiatrist and neurologist.
  • Clinical evaluation focused on identifying psychiatric symptoms and extrapyramidal features.

Main Results:

  • Clinically significant psychiatric symptoms were identified in 11 out of 23 patients.
  • Depressed affect was the most frequent psychiatric finding.
  • A strong correlation was observed between severe depressed affect and severe extrapyramidal symptoms.

Conclusions:

  • Psychiatric symptoms, particularly depression, are prevalent in Wilson's Disease.
  • The severity of psychiatric manifestations, especially depression, is linked to the degree of neurological involvement.