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Updated: May 27, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-(2,3-Dimethyl-phen-yl)-4-methylbenzamide
This study details the crystal structure of a C16H17NO molecule, revealing nearly perpendicular aromatic rings. Intermolecular hydrogen bonds stabilize the structure into chains along the c axis.
Area of Science:
- Crystallography
- Molecular structure analysis
- Supramolecular chemistry
Background:
- Understanding molecular arrangements is crucial in chemistry.
- Crystal structure analysis provides insights into intermolecular forces.
- Hydrogen bonding plays a key role in stabilizing crystal lattices.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C16H17NO.
- To investigate the spatial arrangement of aromatic rings within the molecule.
- To identify and characterize the intermolecular interactions responsible for crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of the dihedral angle between the aromatic rings was performed.
- Identification of hydrogen bonding networks and their role in crystal stabilization.
Main Results:
- The molecule C16H17NO exhibits a dihedral angle of 85.90(5)° between its two aromatic rings, indicating a near-perpendicular orientation.
- Intermolecular N-H⋯O hydrogen bonds were identified as the primary stabilizing force in the crystal lattice.
- These hydrogen bonds link the molecules into C(4) chains that extend along the c axis.
Conclusions:
- The crystal structure of C16H17NO is characterized by near-orthogonal aromatic rings.
- The observed crystal packing is dictated by robust intermolecular N-H⋯O hydrogen bonds forming C(4) chains.
- This structural information contributes to the understanding of molecular assembly in organic solids.
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