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11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-Amino-pyridin-3-ol.
Richard Betz1, Thomas Gerber, Eric Hosten
1Nelson Mandela Metropolitan University, Summerstrand Campus, Department of Chemistry, University Way, Summerstrand, PO Box 77000, Port Elizabeth 6031, South Africa.
Acta Crystallographica. Section E, Structure Reports Online
|November 8, 2011
Summary
This study details the crystal structure of a pyridine derivative (C(5)H(6)N(2)O). Molecules form double layers through hydrogen bonding, revealing insights into intermolecular interactions.
Area of Science:
- Crystallography
- Molecular Chemistry
- Supramolecular Chemistry
Background:
- Pyridine derivatives are important in various chemical applications.
- Understanding molecular structure and intermolecular forces is crucial for materials science.
Purpose of the Study:
- To elucidate the crystal structure of a specific pyridine derivative (C(5)H(6)N(2)O).
- To investigate the hydrogen bonding network and π-π stacking interactions in the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of intra-cyclic bond angles and hydrogen bond geometries was performed.
Main Results:
- The pyridine derivative molecule exhibits approximate C(s) symmetry.
- Intra-cyclic angles range from 118.34(10)° to 123.11(10)°.
- Hydrogen bonds (O-H⋯N, N-H⋯O, N-H⋯N) organize molecules into double layers.
- The shortest π-π stacking distance between molecular π-systems is 3.8887(7) Å.
Conclusions:
- The crystal structure is stabilized by a network of hydrogen bonds, forming double layers.
- The observed π-π stacking suggests potential for electronic interactions within the crystal.
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Overview
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Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...
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