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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
Published on: October 17, 2025
The key to enabling biosurveillance is cooperative technology development.
Peter Emanuel1, Franca Jones, Michael Smith
1U.S. Army Edgewood Chemical and Biological Center, Aberdeen Proving Ground, Maryland 21010-5183, USA. peter.emanuel@us.army.mil
Global biosurveillance requires a coordinated network of interoperable technologies for early detection of infectious disease threats. Achieving this necessitates enhanced cooperation across governments and public-private partnerships for effective national security.
Area of Science:
- Public Health
- National Security
- Epidemiology
Background:
- Biological threats, natural or intentional, pose significant global challenges to public health, economies, and development.
- The U.S. government acknowledges the link between global public health and national security.
- Early warning, detection, and situational awareness are crucial for responding to infectious disease outbreaks.
Purpose of the Study:
- To advocate for a globally distributed network of interoperable biosurveillance technologies.
- To highlight the need for enhanced cooperation in developing and fielding these systems.
- To propose a strategy for integrating the acquisition of global biosurveillance technologies.
Main Methods:
- The commentary suggests a conceptual framework for global biosurveillance.
- It emphasizes the need for interoperable hardware and software systems.
- It calls for interagency and international collaboration in research, development, and acquisition.
Main Results:
- Current levels of cooperation are insufficient for establishing a comprehensive global biosurveillance network.
- A globally distributed network of linked collection nodes is essential for early recognition of disease threats.
- Interoperability of technologies is a key requirement for effective biosurveillance.
Conclusions:
- Enhanced cooperation among U.S. federal agencies and global partners is critical.
- Public-private partnerships and strategic alliances are vital for successful technology acquisition.
- Leveraging existing federal interagency groups can facilitate the integration of global biosurveillance efforts.
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