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Updated: May 27, 2026

Ensemble Force Spectroscopy by Shear Forces
Published on: July 26, 2022
Effect of shear force on the separation of double-stranded DNA
Rakesh Kumar Mishra1, Garima Mishra, M S Li
1Department of Physics, Banaras Hindu University, Varanasi 221 005, India.
Abstract:
Using the Langevin dynamics simulation, we have studied the effects of shear force on the rupture of short double-stranded DNA at different temperatures. We show that the rupture force increases linearly with chain length and approaches the asymptotic value in accordance with the experiment. The qualitative nature of these curves remains almost the same for different temperatures but with a shift in the force. We observe three different regimes in the extension of covalent bonds (backbone) under shear force.
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